Synthesis, characterization and antibacterial studies of Zn (II), Ni(II) and Mn(II) complexes of Streptomycin

I.E. Otuokere, C.B. Iwu

Abstract


Objective: Synthesis and antibacterial studies of Ni(II), Zn(II) and Mn(II) complexes of Streptomycin.

Methods: Ni(II), Zn(II) and Mn(II) complexes of streptomycin were synthesized using refluxing method. The colour, yield, melting point and solubility of metal complexes were determined. Metal complexes were characterized based on UV, IR and 1H NMR spectroscopy. The zone of inhibition against Escherichia coli and staphylococcus aureus at 250mg/ml concentration were evaluated using agar-diffusion techniques.

Results: The solubility studies showed that streptomycin and its metal complexes are hydrophilic.  The electronic spectra of the metal complexes showed intraligand charge transfer (ILCT), ligand to metal charge transfer (LMCT) and d-d transition. The IR and 1H NMR spectroscopic studies showed that coordination of streptomycin were at the OH and ROR functional groups. The zone of inhibition of [Ni(II)C12H39N7O12] against Escherichia coli was (28.17 0.4 mm) which was significantly higher (P<0.05) than others in the group. The inhibitory efficiency of the compounds are as follows [Ni(II)C12H39N7O12] > [Zn(II)C12H39N7O12] > C12H39N7O12 >[Mn(II)C12H39N7O12]. The zone of inhibition of [Ni(II)C12H39N7O12] against staphylococcus aureus  was (11.5 1.11mm) which was significantly higher (P<0.05) than others in the group. The inhibitory efficiency of the compounds are as follows [Ni(II)C12H39N7O12] > [Zn(II)C12H39N7O12] > [Mn(II)C12H39N7O12] > C12H39N7O12.

Conclusions: Based on spectroscopic analysis hexadentate geometry was proposed for the metal complexes. The metal complexes were more potent than the free ligand against Escherichia coli and staphylococcus aureus at 250 mg/ml concentration.


Keywords


Streptomycin, spectroscopy, complexes, nickel, zinc, manganese

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