Pharmacological perspective of neurotransmission basis of alcohol intoxication

Charles Osuji


Alcohol in the human body appears to have an extensive impact on molecular targets in the nervous system. The wide spectrum of physical behavioural abnormalities express by alcoholics is traced to its ability to cross the blood-brain barrier (BBB), intercalates into cell membranes and affects the information processing activities in the brain membranes potential. It is also viewed that the far reaching effects of ethanol in the nervous system which is mediated via the ion channels, receptors and enzymes are primarily caused by its interactions with neurotransmitters. The molecular basis of neurotransmitter mediated alcohol induced behavioural effect is the main focus of this review. In this article the term alcohol is used as a generic name for ethanol (ethyl alcohol), which is the main subject of this discussion.


Alcohol, Neurotransmitter, Psychoactive, Pharmacodynamics, BBB, CNS

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